Effective the week of June 4th, 2012, the Fetal Lung Maturity by FPA will no longer be available. UHS Wilson Laboratory will be offering instead the Lamellar Body Count (LBC) in order to determine fetal lung maturity in assessing the risk for developing respiratory distress syndrome (RDS) in infants born prematurely (32-39 weeks). RDS is associated with preterm birth due to insufficient production of pulmonary surfactant. Surfactant is packaged into lamellar bodies and is excreted into the alveolar space where it forms a monolayer on alveolar surfaces. Lamellar bodies can also pass into the amniotic cavity, and therefore are found in amniotic fluid. Lamellar bodies are similar in size to platelets and can be quantified on a hematology analyzer utilizing the platelet channel and used to estimate fetal lung maturity. LBC’s will be reported with the following reference values:
Immature <15,000 /µL
Indeterminate 15,000-50,000 /µL
Mature >50,000 /µL
Results in the Indeterminate range will reflex an AmnioStat PG (ASPG) to assist in the determination of the risk of RDS.
LBC testing is available 24hr/7 days and STAT. Specimen requirements are at least 1 ml amniotic fluid collected by amniocentesis.
If you have any questions, please call the UHS Laboratory Client Services Department at 763-5780. Thank you .