On April 29th, 2014, the Chemistry laboratories at WMH and BGH will be transitioning to new Chemistry equipment, the Roche Cobas 6000. One of the most significant changes as a result of this transition will be to the Troponin testing offered by the laboratory. Currently, the laboratory offers a Troponin I marker, performed on a Siemens Chemistry platform. With the new Roche Cobas platform, the laboratory will be offering a Troponin T marker. While the goal of utilizing Troponin itself as a cardiac biomarker will remain the same, several differences may be observed with regard to cut-points, ranges and critical values.
The following represents the differences in cut-points (at the 99th percentile), ranges and critical values for the current and new Troponin assays:
CURRENT TROPONIN INFORMATION:
Assay - Siemens Vista TnI (Troponin I)
Cut Point (99th percentile) 0.045 ng/mL @ 10% CV
0.04 – 0.10 Indeterminate
> 0.10 Abnormal
Critical Value >0.1 ng/mL (First Value Only)
NEW TROPONIN INFORMATION:
Assay - Roche Cobas TnT (Troponin T)
Cut Point (99th percentile) 0.01 ng/mL @ 18% CV
Cut Point (99th percentile) 0.03 ng/mL @ 10% CV
0.01 – 0.02 Equivocal
Critical Value >0.02 ng/mL (First Value Only)
In addition, research suggests that relying on a single Troponin value should be avoided in favor of serial testing.
Should there be additional questions, please contact the WMH Chemistry Supervisor, Angela K. Armato, at 763-5780, the BGH Laboratory Supervisor, Rosemary Parkinson, at 763-2366, or the Laboratory Medical Director, Dr.Jagmohan Sidhu, MD, at 763-5780. Thank you.