Thursday, June 25, 2015 at 11:46:49 AM

On June 29th, 2015, the Chemistry laboratories at WMH and BGH will be transitioning to new Chemistry equipment, the Ortho Vitros 5600. One of the most significant changes as a result of this transition will be to the Troponin testing offered by the laboratory. Currently, the laboratory offers a Troponin T marker, performed on a Roche Cobas 6000 platform. With the new Ortho Vitros 5600 platform, the laboratory will be offering a Troponin I marker. While the goal of utilizing Troponin itself as a cardiac biomarker will remain the same, several differences may be observed with regard to cut-points, ranges and critical values.

The following represents the differences in cut-points (at the 99th percentile), ranges and critical values for the current and new Troponin assays:

CURRENT: Roche Cobas TnT (Troponin T)

Cut-Point(99th percentile)

0.01 ng/mL @ 18% CV

0.03 ng/mL @ 10% CV


Negative <0.01 ng/mL

Equivocal 0.01-0.02 ng/mL

Critical Value

>0.02 ng/mL [First Value Only]

NEW: Ortho Vitros Troponin I

Cut-Point (99th percentile)

0.034 ng/mL @ 10% CV


Normal <0.034 ng/mL

Indeterminate 0.034 0.119 ng/mL

Abnormal >/= 0.120 ng/mL

Critical Value:

>/= 0.120 ng/mL [First Value Only]

In addition, research suggests that relying on a single Troponin value should be avoided in favor of serial testing.

Additional questions should be directed to the WMH Chemistry Supervisor, Angela Armato, at 763-5780, the BGH Laboratory Supervisor, Rosemary Parkinson at 763-5780, or the Laboratory Medical Director, Dr. Jagmohan Sidhu, MD at 763-5780.

Thank you.

Return To Home Page